ObjectiveTo evaluate the combination of pembrolizumab, cisplatin and gemcitabine in recurrent platinum-resistant ovarian cancer.MethodsPatients received six cycles of chemotherapy with gemcitabine and cisplatin on day 1 and day 8 of a 21-day treatment cycle.Pembrolizumab was administered on day 1 of cycles 3-6 and as maintenance monotherapy in cycl
Recent efforts to sequence the genomes and transcriptomes of several gymnosperm species have revealed an increased complexity in certain gene families in gymnosperms as compared to angiosperms.One example of this is the gymnosperm sister clade to angiosperm TM3-like MADS-box Horse Leg Straps genes, which at least in the conifer lineage has expanded
Bedform fields from the Piedras River mouth (Huelva, SW Spain) have been studied using side-scan sonar techniques, combined with visual scuba-dives, and direct geometric measuring.The dominant flow regime has been determined from the results in these tidal environments, where erosive processes dominate during ebb, transporting sand as a bedload tow